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Article

Solvent and mutation effects on the nucleation of amyloid beta-protein folding.

Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 2005

Cruz Luis, Urbanc Brigita, Borreguero Jose M, Lazo Noel D, Teplow David B, Stanley H Eugene

Abstract excerpt

Experimental evidence suggests that the folding and aggregation of the amyloid beta-protein (Abeta) into oligomers is a key pathogenetic event in Alzheimer's disease. Inhibiting the pathologic folding and oligomerization of Abeta could be effective in the prevention and treatment of Alzheimer's disease. Here, using all-atom molecular dynamics simulations in explicit solvent, we probe the initial stages of folding...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16339896
DOI: 10.1073/pnas.0509276102
PMCID: PMC1317965

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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