Article
Heritable and non-genetic factors as variables of pharmacologic phenotypes in lymphoblastoid cell lines.
The pharmacogenomics journal - 1 Dec 2010
Stark A L, Zhang W, Mi S, Duan S, O'Donnell P H, Huang R S, Dolan M E
Abstract excerpt
Publicly available genetic and expression data on lymphoblastoid cell lines (LCLs) make them a unique resource for understanding the genetic underpinnings of pharmacological outcomes and disease. LCLs have been used for pharmacogenomic discovery and validation of clinical findings associated with drug response. However, variation in cellular growth rate, baseline Epstein-Barr virus (EBV) copy number and ATP...
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