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Article

Integrating cell-based and clinical genome-wide studies to identify genetic variants contributing to treatment failure in neuroblastoma patients.

Clinical pharmacology and therapeutics - 1 Jun 2014

Pinto N, Gamazon E R, Antao N, Myers J, Stark A L, Konkashbaev A, Im H K, Diskin S J, London W B, Ludeman S M, Maris J M, Cox N J, Cohn S L, Dolan M E

Abstract excerpt

High-risk neuroblastoma is an aggressive malignancy, with high rates of treatment failure. We evaluated genetic variants associated with in vitro sensitivity to two derivatives of cyclophosphamide for association with clinical response in a separate replication cohort of neuroblastoma patients (n = 2,709). To determine sensitivity, lymphoblastoid cell lines (LCLs) were exposed to increasing concentrations of...

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Share to Antineoplastic Agents, Alkylating
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24549002
DOI: 10.1038/clpt.2014.37
PMCID: PMC4029857

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EFS

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