Article
Shared epitope alleles remain a risk factor for anti-citrullinated proteins antibody (ACPA)--positive rheumatoid arthritis in three Asian ethnic groups.
PloS one - 1 Jan 2011
Chun-Lai Too, Padyukov Leonid, Dhaliwal Jasbir Singh, Lundström Emeli, Yahya Abqariyah, Muhamad Nor Asiah, Klareskog Lars, Alfredsson Lars, Larsson Per Tobias, Murad Shahnaz
Abstract excerpt
BACKGROUND: To investigate the associations between HLA-DRB1 shared epitope (SE) alleles and rheumatoid arthritis in subsets of rheumatoid arthritis defined by autoantibodies in three Asian populations from Malaysia. METHODS: 1,079 rheumatoid arthritis patients and 1,470 healthy controls were included in the study. Levels of antibodies to citrullinated proteins (ACPA) and rheumatoid factors were assessed and the...
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