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Article

Metformin suppresses epithelial sodium channel hyperactivation and its associated phenotypes in a mouse model of obstructive lung diseases.

Journal of pharmacological sciences - 1 Jun 2022

Nakashima Ryunosuke, Nohara Hirofumi, Takahashi Noriki, Nasu Aoi, Hayashi Megumi, Kishimoto Tomoki, Kamei Shunsuke, Fujikawa Haruka, Maruta Kasumi, Kawakami Taisei, Eto Yuka, Ueno-Shuto Keiko, Suico Mary Ann, Kai Hirofumi, Shuto Tsuyoshi

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death in the world, and has no radical treatment. Inhibition of amiloride-sensitive epithelial sodium ion channel (ENaC) has now been considered as a potential therapeutic target against COPD. One possible modulator of ENaC is AMP-activated protein kinase (AMPK), a key molecule that controls a wide variety of cellular signals; however,...

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PMID: 35512853
DOI: 10.1016/j.jphs.2022.03.002

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