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Article

Control of voltage-gated K+ channel permeability to NMDG+ by a residue at the outer pore.

The Journal of general physiology - 1 Apr 2009

Wang Zhuren, Wong Nathan C, Cheng Yvonne, Kehl Steven J, Fedida David

Abstract excerpt

Crystal structures of potassium (K(+)) channels reveal that the selectivity filter, the narrow portion of the pore, is only approximately 3-A wide and buttressed from behind, so that its ability to expand is highly constrained, and the permeation of molecules larger than Rb(+) (2.96 A in diameter) is prevented. N-methyl-d-glucamine (NMDG(+)), an organic monovalent cation, is thought to be a blocker of Kv...

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Identifiers

PMID: 19332619
DOI: 10.1085/jgp.200810139
PMCID: PMC2699102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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