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Article

Architecture of a K+ channel inner pore revealed by stoichiometric covalent modification.

Neuron - 1 Mar 1999

Lu T, Nguyen B, Zhang X, Yang J

Abstract excerpt

Inwardly rectifying K+ channels bind intracellular magnesium and polyamines to generate inward rectification. We have examined the architecture of the inner pore of Kir2.1 channels by covalently attaching a constrained number (from one to four) of positively charged moieties of different sizes to the channel. Our results indicate that the inner pore is formed solely by the second transmembrane segment and is...

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Source

Identifiers

PMID: 10197536
DOI: 10.1016/s0896-6273(00)80711-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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