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Article

CYP1A21C, CYP2E15B, and GSTM1 polymorphisms are predictors of risk and poor outcome in head and neck squamous cell carcinoma patients.

Oral oncology - 1 Sept 2009

Olivieri Eloisa Helena Ribeiro, da Silva Sabrina Daniela, Mendonça Fernando Fernandes, Urata Yuri Nagamine, Vidal Daniel Onofre, Faria Marcilia de Araujo Medrado, Nishimoto Inês Nobuko, Rainho Claudia Aparecida, Kowalski Luiz Paulo, Rogatto Silvia Regina

Abstract excerpt

Head and neck squamous cell carcinoma (HNSCC) is associated with environmental factors, especially tobacco and alcohol consumption. Most of the carcinogens present in tobacco smoke are converted into DNA-reactive metabolites by cytochrome P450 (CYPs) enzymes and detoxification of these substances is performed by glutathione S-transferases (GSTs). It has been suggested that genetic alterations, such as...

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Source

Identifiers

PMID: 19442564
DOI: 10.1016/j.oraloncology.2009.03.004

Genes

GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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