Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms in drug-metabolizing enzymes and risk to head and neck cancer: evidence for gene-gene and gene-environment interaction.

Environmental and molecular mutagenesis - 1 Mar 2014

Maurya Shailendra S, Anand Gautam, Dhawan Ankur, Khan Anwar J, Jain Swatantra K, Pant Mohan C, Parmar Devendra

Abstract excerpt

A case-control study involving 750 cases with squamous-cell carcinoma of the head and neck (HNSCC) and an equal number of healthy controls was initiated to investigate the association of polymorphisms in the drug metabolizing genes cytochrome P450 1A1 (CYP1A1), CYP1B1, CYP2E1 and glutathione S-transferase M1 (GSTM1) with the risk of developing cancer. Attempts were also made to identify the role and nature of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Drinking
Share to Amino Acid Substitution

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carcinoma, Squamous Cell

Share to Cytochrome P-450 Enzyme System

Share to Epistasis, Genetic

Share to Gene-Environment Interaction

Share to Glutathione Transferase

Share to Head and Neck Neoplasms

Source

Identifiers

PMID: 24519899
DOI: 10.1002/em.21837

Genes

GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms in drug-metabolizing enzymes and risk to head and neck cancer: evidence for gene-gene and gene-environment interaction.PMID 24519899Read ↗

Gene-environment interactions in determining differences in genetic susceptibility to cancer in subsites of the head and neck.Semantic proximity Read ↗

Interaction of cytochrome P450s with environmental risk factors increases their expression and risk to head and neck cancer.Semantic proximity Read ↗

Polymorphism in cytochrome P4501A1 is significantly associated with head and neck cancer risk.Semantic proximity Read ↗

Cytochrome P450 2E1 and head and neck cancer: interaction with genetic and environmental risk factors.Semantic proximity Read ↗

Clinical Management of Head and Neck Cancer Cases: Role of Pharmacogenetics of CYP2 and GSTs.Semantic proximity Read ↗

Genetic polymorphisms of drug-metabolizing enzymes and susceptibility to head-and-neck squamous-cell carcinoma.Semantic proximity Read ↗

CYP1A2*1C, CYP2E1*5B, and GSTM1 polymorphisms are predictors of risk and poor outcome in head and neck squamous cell carcinoma patients.Semantic proximity Read ↗

Combined effect of smoking and polymorphisms in tobacco carcinogen-metabolizing enzymes CYP1A1 and GSTM1 on the head and neck cancer risk in North Indians.Semantic proximity Read ↗

Interaction of glutathione-s-transferase genotypes with environmental risk factors in determining susceptibility to head and neck cancer and treatment response and survival outcome.Semantic proximity Read ↗

Genetic polymorphisms of smoking-related carcinogen detoxifying enzymes and head and neck cancer susceptibility.Semantic proximity Read ↗

Genetic polymorphisms of CYP1A1, CYP2E1, GSTM1, and GSTT1 associated with head and neck cancer.Semantic proximity Read ↗

Genetic variations and head and neck cancer risks.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.