Article
Role of cytochrome P-450 genetic polymorphisms in oral carcinogenesis.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Jan 2012
Hernando-Rodriguez Miriam, Rey-Barja Natalia, Marichalar-Mendia Xabier, Rodriguez-Tojo Maria J, Acha-Sagredo Amelia, Aguirre-Urizar Jose M
Abstract excerpt
Oral cancer is one of the most frequent head and neck cancers, and epidemiological studies have shown that smoking is a major risk factor in this pathology. However, as not all smokers develop oral cancer, some individuals must be more susceptible to develop this disease. This individual susceptibility has been related to different genetic variants in metabolizing enzymes. The cytochrome P-450 (CYP) family of...
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