Article
Microsomal epoxide hydrolase genotypes and the risk for head and neck cancer.
Head & neck - 1 Jul 2008
Lacko Martin, Roelofs Hennie M J, Te Morsche Rene H M, Voogd Adri C, Oude Ophuis Michael B, Peters Wilbert H M, Manni Johannes J
Abstract excerpt
BACKGROUND: Microsomal epoxide hydrolase (mEH) is an enzyme involved in the metabolism of (pre)carcinogens in tobacco smoke. We investigated whether functional genetic polymorphisms in mEH may have a risk-modifying effect on head and neck carcinogenesis. METHODS: Blood from 429 patients with oral, pharyngeal, and laryngeal carcinoma and 419 healthy subjects was investigated for mEH polymorphisms. RESULTS:...
Topics
- Adult
- Age Distribution
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
- Case-Control Studies
- Cohort Studies
- Epoxide Hydrolases
- Female
- Gene Expression Regulation, Neoplastic
- Genetic Predisposition to Disease
- Genotype
- Head and Neck Neoplasms