Article
UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition.
Cell reports - 17 Oct 2017
Ezponda Teresa, Dupéré-Richer Daphné, Will Christine M, Small Eliza C, Varghese Nobish, Patel Tej, Nabet Behnam, Popovic Relja, Oyer Jon, Bulic Marinka, Zheng Yupeng, Huang Xiaoxiao, Shah Mrinal Y, Maji Sayantan, Riva Alberto, Occhionorelli Manuela, Tonon Giovanni, Kelleher Neil, Keats Jonathan, Licht Jonathan D
Abstract excerpt
Loss or inactivation of the histone H3K27 demethylase UTX occurs in several malignancies, including multiple myeloma (MM). Using an isogenic cell system, we found that loss of UTX leads to deactivation of gene expression ultimately promoting the proliferation, clonogenicity, adhesion, and tumorigenicity of MM cells. Moreover, UTX mutant cells showed increased in vitro and in vivo sensitivity to inhibition of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.