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Article

Role of MHC-linked susceptibility genes in the pathogenesis of human and murine lupus.

Clinical & developmental immunology - 1 Jan 2012

Relle Manfred, Schwarting Andreas

Abstract excerpt

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies against nuclear antigens and a systemic inflammation that can damage a broad spectrum of organs. SLE patients suffer from a wide variety of symptoms, which can affect virtually almost any tissue. As lupus is difficult to diagnose, the worldwide prevalence of SLE can only be roughly estimated to...

Topics

Animals
Complement System Proteins
Disease Models, Animal
Genetic Predisposition to Disease
Heat-Shock Proteins
Humans
Lupus Erythematosus, Systemic
Major Histocompatibility Complex
Mice
Tumor Necrosis Factor-alpha

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Identifiers

PMID: 22761632
DOI: 10.1155/2012/584374
PMCID: PMC3385965

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