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Progressive neuropathology and cognitive decline in a single Arctic APP transgenic mouse model.

Neurobiology of aging - 1 Feb 2011

Rönnbäck Annica, Zhu Shunwei, Dillner Karin, Aoki Mikio, Lilius Lena, Näslund Jan, Winblad Bengt, Graff Caroline

Abstract excerpt

The Arctic APP mutation (E693G) leads to dementia with clinical features similar to Alzheimer disease (AD), but little is known about the pathogenic mechanism of this mutation. To address this question, we have generated a transgenic mouse model, TgAPParc, with neuron-specific expression of human APP with the Arctic mutation (hAPParc). Heterozygous mice from two separate founder lines with different levels of...

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PMID: 19329229
DOI: 10.1016/j.neurobiolaging.2009.02.021

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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