Article
The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic mice.
Neurobiology of aging - 1 Jan 2006
Lord Anna, Kalimo Hannu, Eckman Chris, Zhang Xiao-Qun, Lannfelt Lars, Nilsson Lars N G
Abstract excerpt
The Arctic mutation (APP E693G) is unique, since it is located within the amyloid-beta (Abeta) sequence and leads to Alzheimer's disease (AD). Arctic Abeta peptides more easily form Abeta protofibrils in vitro, but little is known about the pathogenic mechanism of the Arctic mutation in vivo. Here, we analyzed APP transgenic mice with both the Swedish and Arctic mutations (tg-APPArcSwe) and transgenic mice with...
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