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Transgenic mouse models of Alzheimer's disease: phenotype and application.

1 Sept 2003

Abstract excerpt

Alzheimer's disease (AD) is the most common cause of senile dementia, for which there is presently no disease-based treatment. The identification of genetic factors contributing to this disease, and the intense investigation into the cell biology of amyloid precursor protein (APP) and, to some extent, tau, has led to the development of several transgenic mouse models of this disease. These mice show some of the...

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PMID: 14501255
DOI: 10.1097/01.fbp.0000088420.18414.ff

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