Phenotyping of congenic dipeptidyl peptidase 4 (DP4) deficient Dark Agouti (DA) rats suggests involvement of DP4 in neuro-, endocrine, and immune functions.

doi:10.1515/CCLM.2009.064

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Article

Phenotyping of congenic dipeptidyl peptidase 4 (DP4) deficient Dark Agouti (DA) rats suggests involvement of DP4 in neuro-, endocrine, and immune functions.

Clinical chemistry and laboratory medicine - 1 Jan 2009

Frerker Nadine, Raber Kerstin, Bode Felix, Skripuletz Thomas, Nave Heike, Klemann Christian, Pabst Reinhard, Stephan Michael, Schade Jutta, Brabant Georg, Wedekind Dirk, Jacobs Roland, Jörns Anne, Forssmann Ulf, Straub Rainer H, Johannes Sigrid, Hoffmann Torsten, Wagner Leona, Demuth Hans-Ulrich, von Hörsten Stephan

Abstract excerpt

BACKGROUND: Treatment of diabetes type 2 using chronic pharmacological inhibition of dipeptidyl peptidase 4 (DP4) still requires an in-depth analysis of models for chronic DP4 deficiency, because adverse reactions induced by some DP4 inhibitors have been described. METHODS: In the present study, a novel congenic rat model of DP4 deficiency on a "DP4-high" DA rat genetic background was generated (DA.F344-Dpp4(m)/...

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PMID: 19327106
DOI: 10.1515/CCLM.2009.064

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