Article
Extreme reduction of dipeptidyl peptidase IV activity in F344 rat substrains is associated with various behavioral differences.
Physiology & behavior - 1 Oct 2003
Karl Tim, Hoffmann Torsten, Pabst Reinhard, von Hörsten Stephan
Abstract excerpt
The enzyme and binding protein dipeptidyl peptidase IV (DPPIV/CD26) has a unique enzymatic specificity in cleaving dipeptides from neuropeptides, chemokines, and hormones. Thus, DPPIV is potentially involved in the regulation of functions of the immune, endocrine, and nervous systems. In the present study, we compared DPPIV-deficient, mutant Japanese [F344/DuCrj(DPPIV-)] and German [F344/Crl(Ger/DPPIV-)] F344 rat...
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