Article
Effects of a potent melanocortin agonist on the diabetic/obese phenotype in yellow mice.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 1 Jul 1998
Zemel M B, Moore J W, Moustaid N, Kim J H, Nichols J S, Blanchard S G, Parks D J, Harris C, Lee F W, Grizzle M, James M, Wilkison W O
Abstract excerpt
OBJECTIVE: To test the hypothesis that a melanocortin agonist can reverse obesity and insulin resistance in mice overexpressing the agouti protein. EXPERIMENTAL MODEL: Mice overexpressing the agouti protein either by transgene introduction (beta-actin promotor) or by mutation (Ay). DESIGN: NDPMSH was tested for pharmacokinetic suitability. NDPMSH at various doses was administered subcutaneously twice a day for...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.