Effects of a potent melanocortin agonist on the diabetic/obese phenotype in yellow mice.

doi:10.1038/sj.ijo.0800630

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Article

Effects of a potent melanocortin agonist on the diabetic/obese phenotype in yellow mice.

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 1 Jul 1998

Zemel M B, Moore J W, Moustaid N, Kim J H, Nichols J S, Blanchard S G, Parks D J, Harris C, Lee F W, Grizzle M, James M, Wilkison W O

Abstract excerpt

OBJECTIVE: To test the hypothesis that a melanocortin agonist can reverse obesity and insulin resistance in mice overexpressing the agouti protein. EXPERIMENTAL MODEL: Mice overexpressing the agouti protein either by transgene introduction (beta-actin promotor) or by mutation (Ay). DESIGN: NDPMSH...

Topics

Agouti Signaling Protein
Animals
Body Temperature
Body Weight
Diabetes Mellitus
Hair Color
Insulin Resistance
Intercellular Signaling Peptides and Proteins
Male
Mice
Mice, Inbred C57BL
Mice, Obese
Mice, Transgenic

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Obesity

Phenotype

Proteins

Receptors, Pituitary Hormone

Weight Gain

Source

Open in PubMed

Identifiers

PMID: 9705029
DOI: 10.1038/sj.ijo.0800630

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9705029-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.