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Article

CD26/dipeptidyl peptidase 4-deficiency alters thymic emigration patterns and leukcocyte subsets in F344-rats age-dependently.

Clinical and experimental immunology - 1 Feb 2009

Klemann C, Schade J, Pabst R, Leitner S, Stiller J, von Hörsten S, Stephan M

Abstract excerpt

As CD26 (dipeptidyl peptidase 4/DPP4) rapidly truncates incretins N-terminally, including glucagon-like peptide-1, DPP4-inhibitors have been developed for treatment of diabetes type 2. To some extent this is surprising, as CD26/DPP4 is also deeply involved in immune regulation. Long-term pharmacological studies are hampered by off-target inhibition of DPP4-homologues. Therefore, we studied the effects of genetic...

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Share to Dipeptidyl Peptidase 4
Share to Granulocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunologic Memory

Share to Leukocyte Count

Share to Lymphocyte Subsets

Share to Rats, Inbred F344

Share to Thymus Gland

Share to Weight Gain

Source

Open in PubMed Open full text

Identifiers

PMID: 19055685
DOI: 10.1111/j.1365-2249.2008.03839.x
PMCID: PMC2675268

Genes

DPP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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