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Article

Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance.

Proceedings of the National Academy of Sciences of the United States of America - 27 May 2003

Conarello Stacey L, Li Zhihua, Ronan John, Roy Ranabir Sinha, Zhu Lan, Jiang Guoqiang, Liu Franklin, Woods John, Zycband Emanuel, Moller David E, Thornberry Nancy A, Zhang Bei B

Abstract excerpt

Dipeptidyl peptidase IV (DP-IV), a member of the prolyl oligopeptidase family of peptidases, is involved in the metabolic inactivation of a glucose-dependent insulinotropic hormone, glucagon-like peptide 1 (GLP-1), and other incretin hormones. Here, we investigated the impact of DP-IV deficiency on body weight control and insulin sensitivity in mice. Whereas WT mice displayed accelerated weight gain and...

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Identifiers

PMID: 12748388
DOI: 10.1073/pnas.0631828100
PMCID: PMC164531

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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