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Article

APOE-4 genotype and neurophysiological vulnerability to Alzheimer's and cognitive aging.

Annual review of clinical psychology - 1 Jan 2009

Bookheimer Susan, Burggren Alison

Abstract excerpt

Many years before receiving a clinical diagnosis of Alzheimer's disease (AD), patients experience evidence of cognitive decline. Recent studies using a variety of brain imaging technologies have detected subtle changes in brain structure and function in normal adults with a genetic risk for AD; these brain changes have similar pathological features as AD, and some appear to be predictive of future cognitive...

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Identifiers

PMID: 19327032
DOI: 10.1146/annurev.clinpsy.032408.153625
PMCID: PMC3118550

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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