Article
Foxl1 controls the Wnt/beta-catenin pathway by modulating the expression of proteoglycans in the gut.
The Journal of biological chemistry - 16 Nov 2001
Perreault N, Katz J P, Sackett S D, Kaestner K H
Abstract excerpt
Foxl1 is a winged helix transcription factor expressed in the mesenchyme of the gastrointestinal tract. Foxl1 null mice display severe structural defects in the epithelia of the stomach, duodenum, and jejunum. Here we addressed the molecular mechanisms by which Foxl1 controls gastrointestinal differentiation. First we showed that the abnormalities found in the epithelia of the null mice are the result of an...
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