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Article

WNT-pathway activation in IBD-associated colorectal carcinogenesis: potential biomarkers for colonic surveillance.

1 Jan 2010

Abstract excerpt

OBJECTIVES: The Wnt-pathway dominates the sporadic carcinogenesis whereas p53 plays a pivotal role in the colitis-associated counterpart. The expression of Wnt-signaling proteins and p53 during colitis-associated carcinogenesis was determined. METHODS: A tissue microarray was constructed with colonic samples from 5 groups of patients: controls (C, n=10), IBD without neoplasia (IBD, n=12), non-dysplastic IBD with...

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PMID: 20208143
DOI: 10.3233/clo-2009-0503

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