Article
Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1.
Human molecular genetics - 1 May 1999
Xue Y, Gao X, Lindsell C E, Norton C R, Chang B, Hicks C, Gendron-Maguire M, Rand E B, Weinmaster G, Gridley T
Abstract excerpt
The Notch signaling pathway is an evolutionarily conserved intercellular signaling mechanism essential for embryonic development in mammals. Mutations in the human JAGGED1 ( JAG1 ) gene, which encodes a ligand for the Notch family of transmembrane receptors, cause the autosomal dominant disorder Alagille syndrome. We have examined the in vivo role of the mouse Jag1 gene by creating a null allele through gene...
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