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Transcriptional and Translational Control in the Mammalian Unfolded Protein Response

7 Oct 2002

Abstract excerpt

Cells monitor the physiological load placed on their endoplasmic reticulum (ER) and respond to perturbations in ER function by a process known as the unfolded protein response (UPR). In metazoans the UPR has a transcriptional component that up-regulates expression of genes that enhance the capacity of the organelle to deal with the load of client proteins and a translational component that insures tight coupling...

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PMID: 12142265
DOI: 10.1146/annurev.cellbio.18.011402.160624

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