Article

Phosphorylation-Dependent Inhibition of Akt1

2018-07-21

Abstract excerpt

Akt1 is a proto-oncogene that is over active in most cancers. Akt1 activation requires phosphorylation at Thr308; phosphorylation at Ser473 further enhances catalytic activity. Akt1 activity is also regulated via interactions between the kinase domain and the N-terminal auto-inhibitory pleckstrin homology (PH) domain. As it was previously difficult to produce Akt1 in site-specifically phosphorylated forms, the con...

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Literature Corpus work: 3f0f5a20-4b3f-5f46-8516-4ab9ae61a0d1
DOI: 10.20944/preprints201807.0393.v1

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