Glutamate receptor gene (GRIN2B) associated with reduced anterior cingulate glutamatergic concentration in pediatric obsessive-compulsive disorder.

doi:10.1016/j.pscychresns.2009.02.005

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Article

Glutamate receptor gene (GRIN2B) associated with reduced anterior cingulate glutamatergic concentration in pediatric obsessive-compulsive disorder.

Psychiatry research - 15 May 2009

Arnold Paul Daniel, Macmaster Frank P, Richter Margaret A, Hanna Gregory L, Sicard Tricia, Burroughs Eliza, Mirza Yousha, Easter Phillip C, Rose Michelle, Kennedy James L, Rosenberg David R

Abstract excerpt

In this preliminary study, 16 psychotropic-naïve pediatric patients with obsessive-compulsive disorder (OCD) were studied using magnetic resonance spectroscopy (MRS) and genotyped for six candidate polymorphisms in two glutamate system genes. A significant association was identified between the rs1019385 polymorphism of the glutamate receptor, ionotropic, N-methyl-d-aspartate 2B (GRIN2B) and decreased anterior...

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PMID: 19324536
DOI: 10.1016/j.pscychresns.2009.02.005
PMCID: PMC2670773

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