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Article

Association between the NMDA glutamate receptor GRIN2B gene and obsessive-compulsive disorder.

Journal of psychiatry & neuroscience : JPN - 1 Jul 2012

Alonso Pino, Gratacós Mónica, Segalàs Cinto, Escaramís Georgia, Real Eva, Bayés Mónica, Labad Javier, López-Solà Clara, Estivill Xavier, Menchón José M

Abstract excerpt

BACKGROUND: Recent data from neuroimaging, genetic and clinical trials and animal models suggest a role for altered glutamatergic neuro transmission in the pathogenesis of obsessive-compulsive disorder (OCD). The aim of this study was to investigate whether variants in the GRIN2B gene, the gene encoding the NR2 subunit of the N-methyl-D-aspartate (NMDA) glutamate receptor, may contribute to genetic susceptibility...

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Identifiers

PMID: 22433450
DOI: 10.1503/jpn.110109
PMCID: PMC3380099

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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