Article
Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder.
Neuroreport - 22 Mar 2004
Delorme Richard, Krebs Marie-Odile, Chabane Nadia, Roy Isabelle, Millet Bruno, Mouren-Simeoni Marie Christine, Maier Wolfgang, Bourgeron Thomas, Leboyer Marion
Abstract excerpt
Several lines of evidence suggest that obsessive compulsive disorder (OCD) could be the consequence of glutamatergic dysfunction. We performed a case-control study in 156 patients and 141 controls and the transmission disequilibrium test in 124 parent-offspring trios to search for association between OCD and two kainate receptors, GRIK2 and GRIK3. Using three single nucleotide polymorphisms (SNP) in GRIK2 and one...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.