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Article

Trf1 is not required for proliferation or functional telomere maintenance in chicken DT40 cells.

Molecular biology of the cell - 1 May 2009

Cooley Carol, Baird Katie M, Faure Virginie, Wenner Thomas, Stewart Jillian L, Modino Sonie, Slijepcevic Predrag, Farr Christine J, Morrison Ciaran G

Abstract excerpt

The telomere end-protection complex prevents the ends of linear eukaryotic chromosomes from degradation or inappropriate DNA repair. The homodimeric double-stranded DNA-binding protein, Trf1, is a component of this complex and is essential for mouse embryonic development. To define the requirement for Trf1 in somatic cells, we deleted Trf1 in chicken DT40 cells by gene targeting. Trf1-deficient cells proliferated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19321665
DOI: 10.1091/mbc.e08-10-1019
PMCID: PMC2682597

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Trf1 is not required for proliferation or functional telomere maintenance in chicken DT40 cells.PMID 19321665Read ↗

Targeted Deletion Reveals an Essential Function for the Telomere Length Regulator Trf1Semantic proximity Read ↗

Importance of TRF1 for functional telomere structure.Semantic proximity Read ↗

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice.Semantic proximity Read ↗

Effects of double-strand break repair proteins on vertebrate telomere structure.Semantic proximity Read ↗

TRFH domain is critical for TRF1-mediated telomere stabilization.Semantic proximity Read ↗

SUMO-targeted ubiquitin ligase RNF4 plays a critical role in preventing chromosome loss.Semantic proximity Read ↗

TIA-1 or TIAR is required for DT40 cell viability.Semantic proximity Read ↗

Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenanceSemantic proximity Read ↗

PTIP promotes DNA double‐strand break repair through homologous recombinationSemantic proximity Read ↗

DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint.Semantic proximity Read ↗

POT1 and TRF2 Cooperate To Maintain Telomeric IntegritySemantic proximity Read ↗

TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.Semantic proximity Read ↗

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