Article
Combined analysis of the moderating effect of a GRIK1 polymorphism on the effects of topiramate for treating alcohol use disorder.
Drug and alcohol dependence - 1 Aug 2021
Kranzler Henry R, Hartwell Emily E, Feinn Richard, Pond Timothy, Witkiewitz Katie, Gelernter Joel, Crist Richard C
Abstract excerpt
BACKGROUND: In an initial study, we reported that topiramate reduced heavy drinking among individuals who sought to reduce their drinking and that the effect was moderated by a single nucleotide polymorphism (SNP; rs2832407) in GRIK1, which encodes the kainate GluK1 receptor subunit (Kranzler et al., 2014). In a subsequent study that prospectively randomized patients to medication group based on their rs2832407...
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