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Article

Sarcopenia of aging: Underlying cellular mechanisms and protection by calorie restriction

1 Jan 2009

Abstract excerpt

Sarcopenia, the loss of muscle mass and function, is a common feature of aging and impacts on individual health and quality of life. Several cellular mechanisms have been involved in the pathogenesis of this syndrome, including mitochondrial dysfunction, altered apoptotic and autophagic signaling, and, more recently, trace metal dyshomeostasis. Calorie restriction (CR) without malnutrition has been shown to...

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Share to Genetics, Aging, and Longevity in Model Organisms
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PMID: 19319843
DOI: 10.1002/biof.5

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