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Calorie Restriction Increases Muscle Mitochondrial Biogenesis in Healthy Humans

1 Mar 2007

Abstract excerpt

BACKGROUND: Caloric restriction without malnutrition extends life span in a range of organisms including insects and mammals and lowers free radical production by the mitochondria. However, the mechanism responsible for this adaptation are poorly understood. METHODS AND FINDINGS: The current study was undertaken to examine muscle mitochondrial bioenergetics in response to caloric restriction alone or in...

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PMID: 17341128
DOI: 10.1371/journal.pmed.0040076

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