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Article

The fine line between lifespan extension and shortening in response to caloric restriction

1 Jan 2014

Abstract excerpt

Caloric restriction (CR) is generally linked to lifespan extension in various organisms and may limit age-associated diseases. Processes through which caloric restriction promotes lifespan include obesity-countering weight loss, increased DNA repair, control of ribosomal and telomeric DNA repeats, mitochondrial regulation, activation of antioxidants, and protective autophagy. Several of these protective cellular...

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PMID: 24637399
DOI: 10.4161/nucl.27929

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