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Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy

15 Nov 2012

Abstract excerpt

Muscle loss during aging and disuse is a highly prevalent and disabling condition, but knowledge about cellular pathways mediating muscle atrophy is still limited. Given the postmitotic nature of skeletal myocytes, the maintenance of cellular homeostasis relies on the efficiency of cellular quality control mechanisms. In this scenario, alterations in mitochondrial function are considered a major factor underlying...

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PMID: 23154422
DOI: 10.1515/hsz-2012-0247

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