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Article

Inferring population mutation rate and sequencing error rate using the SNP frequency spectrum in a sample of DNA sequences.

Molecular biology and evolution - 1 Jul 2009

Liu Xiaoming, Maxwell Taylor J, Boerwinkle Eric, Fu Yun-Xin

Abstract excerpt

One challenge of analyzing samples of DNA sequences is to account for the nonnegligible polymorphisms produced by error when the sequencing error rate is high or the sample size is large. Specifically, those artificial sequence variations will bias the observed single nucleotide polymorphism (SNP) frequency spectrum, which in turn may further bias the estimators of the population mutation rate theta =4N mu for...

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PMID: 19318520
DOI: 10.1093/molbev/msp059
PMCID: PMC2734145

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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