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Article

Inference of population genetic parameters in metagenomics: a clean look at messy data.

Genome research - 1 Oct 2006

Johnson Philip L F, Slatkin Montgomery

Abstract excerpt

Metagenomic projects generate short, overlapping fragments of DNA sequence, each deriving from a different individual. We report a new method for inferring the scaled mutation rate, theta = 2Neu, and the scaled exponential growth rate, R = Ner, from the site-frequency spectrum of these data while accounting for sequencing error via Phred quality scores. After obtaining maximum likelihood parameter estimates for...

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Identifiers

PMID: 16954540
DOI: 10.1101/gr.5431206
PMCID: PMC1581441

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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