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Article

Correcting estimators of theta and Tajima's D for ascertainment biases caused by the single-nucleotide polymorphism discovery process.

Genetics - 1 Feb 2009

Ramírez-Soriano Anna, Nielsen Rasmus

Abstract excerpt

Most single-nucleotide polymorphism (SNP) data suffer from an ascertainment bias caused by the process of SNP discovery followed by SNP genotyping. The final genotyped data are biased toward an excess of common alleles compared to directly sequenced data, making standard genetic methods of analysis inapplicable to this type of data. We here derive corrected estimators of the fundamental population genetic...

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Identifiers

PMID: 19087964
DOI: 10.1534/genetics.108.094060
PMCID: PMC2644958

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