Article
Usefulness of single nucleotide polymorphism data for estimating population parameters.
Genetics - 1 Sept 2000
Kuhner M K, Beerli P, Yamato J, Felsenstein J
Abstract excerpt
Single nucleotide polymorphism (SNP) data can be used for parameter estimation via maximum likelihood methods as long as the way in which the SNPs were determined is known, so that an appropriate likelihood formula can be constructed. We present such likelihoods for several sampling methods. As a test of these approaches, we consider use of SNPs to estimate the parameter Theta = 4N(e)micro (the scaled product of...
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