Article
GBStools: A Statistical Method for Estimating Allelic Dropout in Reduced Representation Sequencing Data.
PLoS genetics - 1 Feb 2016
Cooke Thomas F, Yee Muh-Ching, Muzzio Marina, Sockell Alexandra, Bell Ryan, Cornejo Omar E, Kelley Joanna L, Bailliet Graciela, Bravi Claudio M, Bustamante Carlos D, Kenny Eimear E
Abstract excerpt
Reduced representation sequencing methods such as genotyping-by-sequencing (GBS) enable low-cost measurement of genetic variation without the need for a reference genome assembly. These methods are widely used in genetic mapping and population genetics studies, especially with non-model organisms. Variant calling error rates, however, are higher in GBS than in standard sequencing, in particular due to restriction...
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