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Article

A SNP discovery method to assess variant allele probability from next-generation resequencing data.

Genome research - 1 Feb 2010

Shen Yufeng, Wan Zhengzheng, Coarfa Cristian, Drabek Rafal, Chen Lei, Ostrowski Elizabeth A, Liu Yue, Weinstock George M, Wheeler David A, Gibbs Richard A, Yu Fuli

Abstract excerpt

Accurate identification of genetic variants from next-generation sequencing (NGS) data is essential for immediate large-scale genomic endeavors such as the 1000 Genomes Project, and is crucial for further genetic analysis based on the discoveries. The key challenge in single nucleotide polymorphism (SNP) discovery is to distinguish true individual variants (occurring at a low frequency) from sequencing errors...

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PMID: 20019143
DOI: 10.1101/gr.096388.109
PMCID: PMC2813483

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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