Article
[Genetic basis of systemic sclerosis].
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae - 1 Feb 2009
Yu Jia, Zuo Ya-Gang, Sun Qiu-Ning
Abstract excerpt
Systemic sclerosis (SSc) is a connective tissue disease characterized by extensive fibrosis, vasculopathy, and activation of the immune system. Its pathogenesis and mechanisms have not been identified. Studies have shown that environmental and genetic factors are involved in the pathogenesis and development of SSc. Although the concordance for the disease among identical twins is low, concordance for...
Topics
- Fibrillins
- Genetic Predisposition to Disease
- Humans
- Microfilament Proteins
- Polymorphism, Genetic
- Protein Tyrosine Phosphatases
- Scleroderma, Systemic
- Tumor Necrosis Factor-alpha