Genetic implications in the pathogenesis of systemic sclerosis.

doi:10.1111/1756-185X.13344

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Article

Genetic implications in the pathogenesis of systemic sclerosis.

International journal of rheumatic diseases - 1 Aug 2018

Rezaei Ramazan, Aslani Saeed, Dashti Navid, Jamshidi Ahmadreza, Gharibdoost Farhad, Mahmoudi Mahdi

Abstract excerpt

Systemic sclerosis (SSc) is a chronic autoimmune disease of the connective tissues of unknown etiology, characterized mainly by fibrosis of the skin, vascular abnormalities, and systemic involvement of other organs, such as gastrointestinal tract, kidneys, lungs, and heart. SSc has been associated with a complex etiology with the involvement of both environmental and genetic factors in the onset and outcome of...

Topics

Animals
Cytokines
Genetic Markers
Genetic Predisposition to Disease
Humans
Major Histocompatibility Complex
Pharmacogenomic Variants
Phenotype
Precision Medicine
Prognosis
Risk Factors
Scleroderma, Systemic

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PMID: 30146749
DOI: 10.1111/1756-185X.13344

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