Updating the genetics of systemic sclerosis.

Abstract excerpt

PURPOSE OF REVIEW: Systemic sclerosis (SSc) is a connective tissue disease characterized by early generalized microangiopathy, immune system disturbances and massive deposits of collagen and other matrix substances in the connective tissue. Although rare, SSc presents a major medical challenge, being recognized as the most severe connective tissue disorder in terms of its prognosis. Molecular biology has provided...

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