Article
Genetic basis for systemic sclerosis.
Joint bone spine - 1 Dec 2007
Allanore Yannick, Wipff Julien, Kahan André, Boileau Catherine
Abstract excerpt
Among the connective tissue diseases, systemic sclerosis is an orphan disease in which diffuse connective tissue alterations lead to multi-organ involvement. Environmental factors implicated in triggering this multifactorial disease include crystalline silica, chlorine solvents, welding vapors, and various other solvents. Clustering within families indicates a role for genetic factors. Although concordance for...
Topics
- Fibrillin-1
- Fibrillins
- Genetic Predisposition to Disease
- Humans
- Microfilament Proteins
- Osteonectin
- Polymorphism, Genetic
- Receptors, Transforming Growth Factor beta
- Scleroderma, Systemic