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Article

Evolutionary and functional epitopes of the Spätzle protein: new insights into activation of the Toll receptor.

Cellular and molecular life sciences : CMLS - 1 May 2009

Wang Y, Zhu S

Abstract excerpt

Spätzle, a dimeric ligand, binds to the Drosophila Toll receptor and activates the signal pathway functioning in both embryonic patterning and innate immunity. Here, we used the evolutionary trace approach based on phylogenetic information to predict the evolutionary epitope of Spätzle and found that it mainly clusters in several adjacent loops of Spätzle far from the cystine-knot structural domain. We designed...

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Identifiers

PMID: 19308321
DOI: 10.1007/s00018-009-9028-3
PMCID: PMC11131468

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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