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Article

Structure of the Toll-Spätzle complex, a molecular hub in <i>Drosophila</i> development and innate immunity

14 Apr 2014

Abstract excerpt

Drosophila Toll receptors are involved in embryonic development and the immune response of adult flies. In both processes, the only known Toll receptor ligand is the human nerve growth factor-like cystine knot protein Spätzle. Here we present the crystal structure of a 1:1 (nonsignaling) complex of the full-length Toll receptor ectodomain (ECD) with the Spätzle cystine knot domain dimer. The ECD is divided into...

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PMID: 24733933
DOI: 10.1073/pnas.1320678111

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