Article
The phylogenetic analysis of tetraspanins projects the evolution of cell-cell interactions from unicellular to multicellular organisms.
Genomics - 1 Dec 2005
Huang Shengfeng, Yuan Shaochun, Dong Meiling, Su Jing, Yu Cuiling, Shen Yang, Xie Xiaojin, Yu Yanhong, Yu Xuesong, Chen Shangwu, Zhang Shicui, Pontarotti Pierre, Xu Anlong
Abstract excerpt
In animals, the tetraspanins are a large superfamily of membrane proteins that play important roles in organizing various cell-cell and matrix-cell interactions and signal pathways based on such interactions. However, their origin and evolution largely remain elusive and most of the family's members are functionally unknown or less known due to difficulties of study, such as functional redundancy. In this study,...
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