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Article

A Drosophila pattern recognition receptor contains a peptidoglycan docking groove and unusual L,D-carboxypeptidase activity.

PLoS biology - 1 Sept 2004

Chang Chung-I, Pili-Floury Sébastien, Hervé Mireille, Parquet Claudine, Chelliah Yogarany, Lemaitre Bruno, Mengin-Lecreulx Dominique, Deisenhofer Johann

Abstract excerpt

The Drosophila peptidoglycan recognition protein SA (PGRP-SA) is critically involved in sensing bacterial infection and activating the Toll signaling pathway, which induces the expression of specific antimicrobial peptide genes. We have determined the crystal structure of PGRP-SA to 2.2-A resolution and analyzed its peptidoglycan (PG) recognition and signaling activities. We found an extended surface groove in...

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Identifiers

PMID: 15361936
DOI: 10.1371/journal.pbio.0020277
PMCID: PMC515366

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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